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By integrating the network graph and the topological attributes table, we identified five key targets associated with UC, including REN, LNPEP, HLA-A, OXTR, and SIRT1

251 However, aurora kinase A (AURKA), an important mitosis regulator, increases the phosphorylation of GSK-3 and inactivates the protein destruction complex, which stimulates the upregulation of -catenin expression and promotes liver regeneration

Results can vary according to assay design, cell line, species model, concentration range, storage history, handling conditions, and analytical methodology

doi: 10.1111/febs.16272 124 ChenYFangZMYiXWeiXJiangDS

Species are organized taxonomically (fish, birds, non-human mammals, and humans)

Among the different target genes, BMAL1 and CLOCK also promote the expression of the components of the negative arm of the molecular clock, such as period ( PER1, PER2, PER3 ) and cryptochrome ( CRY1, CRY2 )